Harvard
researchers discover a hormone released by exercise.
When you're taking a brisk walk on a
beautiful day, what are you thinking about? The sun, the breeze, how good it
feels to loosen up the stiff parts. The last thing you're thinking about as you
pick up the pace is what's happening to your body chemistry.
When you exercise, your body chemistry
changes in ways that we only now are coming to understand. Over the past 20
years, scientists have identified natural molecules in all of us that influence
our appetite and our metabolism—and, hence, our weight. Now, researchers at
Harvard Medical School and elsewhere are identifying the molecules that not
only affect our weight, but also cause other health benefits of exercise.
"Our muscle cells need a source of
energy when they exercise," says Dr. Anthony Komaroff, a professor at
Harvard Medical School. "Muscles get that energy by burning fat and sugar
brought to them by the blood. That's been known for nearly a century. However,
it's not the whole story. "
The hormone irisin
In January 2012, a research team led by Dr.
Bruce Spiegelman, a Harvard Medical School professor, published a new study in
the journal Nature. The study was done in mice, but may well apply to
humans. The study showed that exercising muscle produces a hormone called
irisin.
"Irisin travels throughout the body in
the blood, and alters fat cells," explains Dr. Komaroff. "Body fat is
stored inside fat cells. Most of these fat cells are called white fat cells,
and their function is to store fat."
White fat vs. brown fat
Why do we store fat? When we eat more
calories than we burn by exercise, the extra calories have to go somewhere.
They're stored partly as fat. Our distant ancestors didn't eat as regularly as
we do. Forty thousand years ago on the Serengeti, our ancestors were able to
get a serious meal only a few times each week. In between meals, they needed
some source of energy. A large part of it came from the fat they stored away
after a meal.
In 2009, studies from Harvard Medical School
and elsewhere discovered that humans have not only white fat cells but also
brown fat cells.
"Brown fat cells don't store fat: they
burn fat. If your goal is to lose weight, you want to increase the number of
your brown fat cells and to decrease your white fat cells," says Dr.
Komaroff.
Irisin does that, at least in mice. And those
newly-created brown fat cells keep burning calories after exercise is over. But
it gets better.
Irisin's other effects
We've known for some time that a regular
program of moderate exercise protects us against type 2 diabetes. For example,
a lifestyle program that included regular moderate exercise reduced the risk of
developing type 2 diabetes by nearly 60%—more than any medicine yet invented.
How does that happen? Irisin may be an important part of the answer. In
addition to its effect in creating brown fat cells, it also helps prevent or
overcome insulin resistance, which leads to type 2 diabetes.
Although Dr. Spiegelman did his studies in
mice, he found that humans have irisin, too. While not yet proven, it is very
likely that irisin has similar effects in humans.
"Studies like these are just plain
interesting, in and of themselves," says Dr. Komaroff. "They help us
to understand better how our body works. However, the discovery of irisin also
could have some very practical and beneficial applications. Theoretically,
irisin could become a treatment to help us maintain a healthy body weight and
reduce the risk of diabetes."
Yes, other medicines with a similar promise have
come and gone. However, irisin is not an unnatural pharmaceutical. Rather, it's
part of our natural body chemistry. That may make it more potent and less
likely to have adverse effects. So there is justifiable excitement about the
discovery of irisin, and about the speed with which science is discovering the
chemistry of exercise, appetite, metabolic rate and body weight.
However, our environment, and its effect on
our own behavior, plays a huge role in determining how much we exercise and how
much we eat, and therefore how much we weigh.
"We don't have to wait for a magic
potion," says Dr. Komaroff. "We already have a proven treatment that
profoundly protects our health: exercise."
http://www.health.harvard.edu/newsletters/Harvard_Health_Letter/2012/June/major-fat-burning-discovery